Clinical significance of HPV-DNA testing for precancerous cervical lesionS
نویسندگان
چکیده
Cervical screening by using cytology was proven efficient in reducing the mortality secondary to cervical cancer, but this method has limitations. High risk HPV infection is essential for cervical cancer development so HPV testing is a new tool used for screening patients for cervical neoplasia. HPV testing was proven most useful for women over 30 years old, in cases in which cytology identified ASC-US and after treatment for CIN. This article outlines the clinical significance of HPV-DNA testing for precancerous cervical lesions and the evidence that stands behind these recommendations.
منابع مشابه
HPV-DNA testing for patients with ASC-US helps identify the women who have a high risk for precancerous cervical lesions
BACKGROUND The cytological interpretation of ASC-US represents a category of morphologic uncertainty. For patients with this result, other tests are necessary in order to determine the risk for cervical lesions. MATERIALS AND METHODS 198 patients with ASC-US cytology have been analyzed between 2008 and 2013. All the patients included in the study have subsequently had a high oncogenic HPV tes...
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Cervical cancer is the second most common female cancer in Thailand and worldwide (IARC, 2005; Ferlay et al., 2010). Persistence high risk HPV infection is known as a leading cause of cervical cancer (Schiffman and Kjaer, 2003; IARC, 2005). Most of the cervical cancer cases developed in the developing countries. Despite of the wide spreading of the disease, cervical cancer is one of the prevent...
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Of the many types of human papillomavirus (HPV), more than 30 infect the genital tract. The association between certain oncogenic (high-risk) strains of HPV and cervical cancer is well established. Although HPV is essential to the transformation of cervical epithelial cells, it is not sufficient, and a variety of cofactors and molecular events influence whether cervical cancer will develop. Ear...
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OBJECTIVE Expression of the viral E6/E7 oncogenes of high-risk human papillomaviruses (HR-HPV) is necessary for malignant conversion and maintenance in cervical tissue. In order to determine whether HR-HPV E6/E7 mRNA testing more effectively predicts precancerous lesions and invasive cervical cancer than HR-HPV DNA testing, we aimed to compare triage using HR-HPV E6/E7 mRNA testing by APTIMA HP...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2014